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ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will boost the amount or effect of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Acute ergot toxicity characterized by vasospasm and tissue ischemia has become associated with coadministration of ritonavirfluvoxamine will enhance the amount or result of er